It was another game and another win for Lyon in Top 14, where Castres were defeated by Toulouse on Saturday.
Racing 92 dominated the second half to beat Pau before La Rochelle were beaten by Toulon at Stade Mayol.
Despite seeing their try line breached for the first time this season, Lyon maintained a 100 per cent start to the season in the Top 14.
Toulon and Agen each won in the Top 14 on Sunday, with Racing 92 unable to complete a turnaround while Montpellier were outplayed.
Toulouse won the Top 14 last season but they have been beaten in each of their first two matches at the start of the 2019-20 campaign.
There were shock wins for Bayonne and Bordeaux-Begles as the Top 14 returned for the 2019-20 season on Saturday.
Munster, Racing 92 and the Ospreys will take on holders Saracens in the pool stage of the 2019-20 European Champions Cup.
La Rochelle finished behind Racing 92 in the Top 14 regular season but dumped the Paris club out of the play-offs on Friday.
There will be a new Top 14 champion after Castres missed out on a top-six finish with a final-day defeat to Toulon.
Perpignan suffered a 23rd loss in 25 Top 14 games as Louis Dupichot and Simon Zebo scored hat-tricks in Racing 92's 52-14 victory.