Zack Holmes scored 15 points as Toulouse extended their lead at the Top 14 summit, while Stade Francais boosted their play-off hopes.
Having sustained a suspected concussion while playing for Top 14 at the weekend, Sergio Parisse will sit out Italy's clash with Ireland.
Perpignan finally had a win to celebrate, while Clermont Auvergne were too good for Bordeaux-Begles in Top14.
Toulouse replaced Clermont Auvergne at the summit of the Top 14 table on Sunday, while Toulon scored two late tries to stun Stade Francais.
For the second time in two days, a side racked up a century of points in the Challenge Cup as Bristol Bears routed Enisei 107-19.
Zebre led at half-time of their European Challenge Cup match at La Rochelle, but the hosts fought back in stunning fashion on Friday.
Racing 92's win over Toulon will not have made pleasant viewing for France coach Jacques Brunel as Teddy Thomas was injured.
The battle between top and bottom in the Top 14 table stayed true to form, Clermont running out comfortable winners on the road.
Stade Francais moved up to fifth in the table as Toulon and Racing 92 ran out convincing winners in Saturday's Top 14 action.
Tributes were paid to teenager Nicolas Chauvin before and after Stade Francais got the better of the Ospreys in Paris.