Jaap Stam's first game in charge of Cincinnati ended in a heavy defeat to Columbus Crew.
Ahead of the season resuming next month, an Atlanta United player has contracted COVID-19.
A clash between Orlando City and Inter Miami will get the MLS season back underway.
Inter Miami slumped to a second straight loss to start the MLS season, beaten by DC United.
Atlanta United striker Josef Martinez scored 77 goals over the past three MLS seasons, but he tore his ACL in their opening 2020 game.
Thierry Henry's Montreal Impact came from behind to win on the opening day of the MLS season.
With the season set to kick off, here is a selection of the best Opta facts related to MLS.
A day after Seattle Sounders shocked Los Angeles FC, Toronto stunned Atlanta United to move through to the November 10 final.
The MLS Best XI for 2019 has been announced, with prolific strikers Zlatan Ibrahimovic and Carlos Vela the standout names.
Zlatan Ibrahimovic and LA Galaxy lost an eight-goal thriller against Los Angeles FC in the MLS play-offs.