London Irish battled to claim a draw at Bristol Bears despite seeing Ollie Hoskins sent off on the stroke of half-time.
Northampton Saints made it four wins from five to go top of the Premiership, while Exeter Chiefs thrashed Wasps.
In their first Premiership match since accepting a 35-point deduction for breaching salary-cap rules, Saracens defeated Bath 25-12.
Experienced England full-back Mike Brown will miss the rest of the Premiership season, Harlequins have confirmed.
Captain Joe Launchbury believes the future is bright for Wasps after signing a new deal.
Anthony Watson's knee injury is not as serious as first feared, but he may not play again this year.
After one appearance at the Rugby World Cup, England international Joe Cokanasiga appears set for a lengthy spell on the sidelines.
After opting not to appeal against a huge fine for breaching the salary cap, Saracens have forked out for another sanction breach.
England could be without some key players for the Six Nations due to the situation at Saracens, according to Eddie Jones.
Despite initially saying they would challenge a huge points deduction for salary cap breaches, Saracens will not launch an appeal.