Cristian Garin became the first Chilean player to win a home event since Fernandez Gonzalez in 2009.
Pierre-Hugues Herbert forced Daniil Medvedev into a deciding set, but the top seed came through to claim Open 13 Provence glory.
Cristian Garin defeated Daniel Elahi Galan in Saturday's semi-final and will play Facundo Bagnis in the Chile Open final.
Pierre-Hugues Herbert carries the hopes of France in Sunday's Open 13 final in Marseille as he prepares to face Daniil Medvedev.
A kind draw is getting kinder for Cristian Garin, whose hopes of a home victory were boosted while he won again.
Stefanos Tsitsipas has been champion twice in Marseille, but he will not make it three in a row this year after a quarter-final defeat.
The draw has opened up nicely for top seed Cristian Garin as he aims to win an ATP Tour event in his own country for the first time.
Roger Federer used this week in Doha as "a stepping stone" as he recovers full match fitness but will not play Dubai.
ATP Tour great Roger Federer could not follow up victory in his first match for over a year as he went down to Nikoloz Basilashvili.
World number two Rafael Nadal has been struggling with a back injury and has been forced to withdraw from the Dubai Tennis Championships.