The Waratahs secured back-to-back Super Rugby wins for the first time in almost a year and a half on the Gold Coast.
The Blues and the Crusaders' respective Super Rugby Aotearoa seasons are over after their match on Sunday was called off.
Trailing at half-time, the Crusaders overcame the Highlanders to dodge a make-or-break date with the Blues in Super Rugby Aotearoa.
The Waratahs scored 38 points without reply in the first half as they cut loose in the rain to thrash the Reds in Sydney.
The Hurricanes still have an outside shot at the Super Rugby Aotearoa title but it was another miserable day for the Chiefs.
The Brumbies came unstuck in the rain at Leichhardt Oval, where the Rebels scored four first-half tries.
The influential Jordie Barrett has decided to stay in Wellington with the Hurricanes for another season.
Sunday's bonus-point win at Forsyth-Barr Stadium moved the Blues to 22 points, just two points adrift of Super Rugby leaders the Crusaders.
The Brumbies were victorious once again in Super Rugby AU, though left it late to see off the Reds in Canberra.
The Chiefs were unable to mark Aaron Cruden's 100th appearance with a victory as the Crusaders bounced back from losing to the Hurricanes.