Eddie Jones says Manu Tuilagi should be fit to return against Ireland, while fellow centre Henry Slade will be monitored.
Caelan Doris has recovered from a head injury, but the Ireland number eight has to settle for a place on the bench against England.
Scotland, who are yet to score a try in this year's Six Nations, have made three changes to their XV to face Italy in Rome.
Hallam Amos returns to the Wales squad for this weekend's Six Nations clash with pace-setters France, replacing Cardiff team-mate Owen Lane.
Mako Vunipola has flown to Tonga and will not be available for England's Six Nations encounter with unbeaten Ireland this weekend.
Scotland have called up the fit-again Sam Skinner and Matt Fagerson ahead of their clash with Italy in Rome on February 22.
After opting out of playing against Pakistan, Mushfiqur Rahim is selected in a 16-man squad for the one-off Test with Zimbabwe.
There was mixed news from head coach Eddie Jones for England on the injury front on Thursday.
Owen Williams suffered a hamstring injury while warming up ahead of Wales' Six Nations defeat to Ireland on Saturday.
Vincent Rattez, a try-scorer against England, will play no further part in the Six Nations for France.