Sorana Cirstea, the 2008 champion, could not repeat her Tashkent Open success against Alison Van Uytvanck in Saturday's final.
Eleven years on from her first and only WTA Tour title to date, Sorana Cirstea is back in the Tashkent Open final.
Fifth seed Kristyna Pliskova is into the Tashkent Open semi-finals, along with Alison Van Uytvanck, Sorana Cirstea and Katarina Zavatska.
Dayana Yastremska, the 19-year-old from Ukraine, will look to deny Caroline Garcia another triumph on home soil.
Caroline Wozniacki's participation in the Madrid Open was brief, while Elina Svitolina suffered an early exit on day two.
For the second time in as many matches at the Ladies Open Lugano, Polona Hercog came from a set down to progress.
Kateryna Kozlova claimed the opening set against Alison Van Uytvanck but the reigning champion hit back to reach the last four.
Caroline Wozniacki was well below her best as the Australian Open champion suffered a straight-sets defeat to Lesia Tsurenko on Thursday.
After reaching the semi-finals of a WTA Tour event for the first time since 2016, Eugenie Bouchard received further good news.
Eugenie Bouchard is in position to challenge for the Ladies Championship Gstaad as the seeds tumble.