The Premier Leagues Golden Boot and Golden Glove are both up for grabs on Sunday, while Kevin De Bruyne is chasing an all-time mark.
Ederson is back in Manchester City's FA Cup line-up and has a strong Arsenal forward line to contend with at Wembley.
Claudio Bravo has been Manchester City's goalkeeper in domestic cups this season but injury will keep him out Saturday's semi-final.
Pep Guardiola spoke to reporters following Manchester City's shock loss to Southampton.
Manchester City goalkeeper Ederson has been key to the club's recent success and has praised Pep Guardiola for improving his all-round game.
Ederson is famed for his aggressive goalkeeping style but admitted his collision with Eric Garcia "did not go the way I wanted".
Leroy Sane is back in training with Manchester City but has only managed a solitary outing with the club's U23 side since ACL surgery.
Ilkay Gundogan is not happy with Bruno Fernandes for his role in helping Manchester United beat Manchester City.
Manchester United completed a league double over Manchester City to leave Liverpool on the verge of a first Premier League title.
Ederson was culpable for both Manchester United goals as Manchester City lost 2-0 at Old Trafford but Pep Guardiola defended his goalkeeper.