Denis Shapovalov will face Andrey Rublev in the last eight at the Winston-Salem Open.
Denis Shapovalov was untroubled by Tennys Sandgren in the Winston-Salem Open second round.
There were upsets galore at the German Tennis Championships on Monday as Benoit Paire and Cristian Garin were beaten.
Kyle Edmund let a two-set lead slip against Fernando Verdasco, while Stan Wawrinka also lost as Wimbledon champion Novak Djokovic advanced.
There were plenty of shocks at the Nature Valley International, with top seed Guido Pella among several favourites knocked out.
Joao Sousa slipped out of the Antalya Open after a 6-4 7-6 (13-11) defeat to Lorenzo Sonego, as Viktor Troicki scraped into the main draw.
Roger Federer and Rafael Nadal advanced in three sets, but Stan Wawrinka required five to see off Stefanos Tsitsipas at the French Open.
Stan Wawrinka lifted a young fan to safety in Paris, while Marin Cilic was ousted by Grigor Dimitrov in a classic.
Felix Auger Aliassime missed out on a maiden ATP Tour title as he was beaten in straight sets by Benoit Paire in Lyon.
World number five Alexander Zverev appears to have found form at the right time heading into the French Open.