Diego Rossi continued his goalscoring form as Los Angeles FC eased past the Seattle Sounders.
Chris Wondolowski scored his 161st MLS goal as San Jose Earthquakes clinched top spot in their group on Sunday.
A first senior goal for Mauricio Pineda was enough for Chicago Fire to win their MLS is Back tournament opener.
Both goalkeepers had saves to make as the Seattle Sounders and San Jose Earthquakes drew.
A clash between Orlando City and Inter Miami will get the MLS season back underway.
Inter Miami slumped to a second straight loss to start the MLS season, beaten by DC United.
Inter Miami made their debut on Sunday but the league's expansion franchise left Los Angeles emptyhanded.
Thierry Henry and David Beckham are back in MLS, while there is intrigue surrounding both Los Angeles clubs after Zlatan Ibrahimovic's exit.
With the season set to kick off, here is a selection of the best Opta facts related to MLS.
Second-half substitute Victor Rodriguez scored the pick of the goals as Seattle Sounders beat Toronto FC in the MLS Cup final.