A clash between Orlando City and Inter Miami will get the MLS season back underway.
Inter Miami slumped to a second straight loss to start the MLS season, beaten by DC United.
Inter Miami made their debut on Sunday but the league's expansion franchise left Los Angeles emptyhanded.
Thierry Henry and David Beckham are back in MLS, while there is intrigue surrounding both Los Angeles clubs after Zlatan Ibrahimovic's exit.
With the season set to kick off, here is a selection of the best Opta facts related to MLS.
Second-half substitute Victor Rodriguez scored the pick of the goals as Seattle Sounders beat Toronto FC in the MLS Cup final.
A day after Seattle Sounders shocked Los Angeles FC, Toronto stunned Atlanta United to move through to the November 10 final.
Seattle Sounders made it through to their third MLS final after upstaging LAFC in Los Angeles on Tuesday.
Alejandro Pozuelo's dramatic 90th-minute penalty settled the Conference semi-final at Citi Field in New York on Wednesday.
Derby County-bound Wayne Rooney was helpless as DC suffered a 5-1 defeat to Toronto after extra time in the opening round of the play-offs.