Chicago Fire were denied a crucial goal by VAR as Vancouver Whitecaps progressed to the last 16 in Florida.
Chris Wondolowski scored his 161st MLS goal as San Jose Earthquakes clinched top spot in their group on Sunday.
A first senior goal for Mauricio Pineda was enough for Chicago Fire to win their MLS is Back tournament opener.
MLS decided to remove Nashville SC from its MLS is Back Tournament after 10 players returned positive coronavirus tests.
A clash between Orlando City and Inter Miami will get the MLS season back underway.
Inter Miami slumped to a second straight loss to start the MLS season, beaten by DC United.
Inter Miami made their debut on Sunday but the league's expansion franchise left Los Angeles emptyhanded.
Manchester United target Donny van de Beek is reportedly poised to join Real Madrid from Ajax ahead of the 2020-21 campaign.
Toronto FC will hope to follow the Raptors in delivering success. But this would not be the first city to enjoy multiple triumphs in a year.
Ottmar Hitzfeld gave Bastian Schweinsteiger his Bayern Munich debut in 2002 and he reflected on the privilege of working with an icon.