Wounded Ireland suffered their first home defeat to France for a decade on the back of their loss to Wales in Cardiff.
Ireland can become Six Nations champions by winning their final two matches in the disrupted 2020 season, with Italy and France to come.
Ireland were beaten 24-12 at Twickenham, with head coach Andy Farrell left to concede that England were much the better side.
Johnny Sexton has played only three matches since the Rugby World Cup, but Andy Farrell saw an "outstanding" display from Ireland's captain.
Ireland should be a major threat in the Six Nations at the start of a new era under head coach Andy Farrell.
Johnny Sexton and Jordan Larmour have been joined by uncapped number eight Caelan Doris in Ireland's team to face Scotland.
Johnny Sexton expects to lead Ireland against Scotland in Dublin and Jordan Larmour is expected to be in contention.
Andy Farrell has called up five uncapped players into his first Ireland squad, with Johnny Sexton confirmed as the team's captain.
Ireland have named a 45-man squad to train in Dublin that omits Rob Kearney, Jordi Murphy, Sean Cronin, Jack Carty and Kieran Marmion.
Rugby league, not union, was in the blood for Owen Farrell but on Saturday he will battle to lift the greatest prize in the latter code.