Joao Felix risks missing Atletico Madrid's big clash at Sevilla on Sunday after returning from international duty with an ankle problem.
On his first start for Portugal in the World Cup qualifiers, Joao Felix struggled to make an impact before going off with an injury.
Portugal needed an own goal to overcome minnows Azerbaijan, but boss Fernando Santos was not concerned about his side's display.
Joao Felix, who is set to start for Atletico Madrid at Chelsea, says his relationship with Diego Simeone is "very good".
Cristiano Ronaldo reportedly wants to re-join LaLiga champions Real Madrid.
Atletico Madrid boss Diego Simeone appeared to question Joao Felix's work-rate this week but insisted his remarks were misconstrued.
Diego Simeone was asked about Joao Felix's goal celebration in Atletico Madrid's victory at Villarreal on Sunday.
Joao Felix added to Alfonso Pedraza's own goal as Atletico Madrid restored their five-point lead at the summit of LaLiga.
Diego Simeone will be able to call upon Joao Felix once again on Wednesday, though he is yet to decide if he will start.
After Joao Felix and Moussa Dembele contracted COVID-19 last week, two more Atletico Madrid players have tested positive.