Guinea made the most of the man advantage as they beat Burundi 2-0 in Cairo to remain in with a chance of reaching the last 16 of the AFCON.
Naby Keita was replaced with 20 minutes to go in Guinea's defeat to Nigeria but said he is "fine" and could feature against Burundi.
After impressing for a second consecutive match, Madagascar earned their first AFCON win against Burundi on Thursday.
Burundi already have an uphill task after losing their first AFCON game, though Madagascar are aware of the threat they can pose.
Group B favourites Nigeria were frustrated by a well-organised Burundi outfit but a late Odion Ighalo strike sealed all three points.
Nigeria won the AFCON in their most recent participation and they begin their quest for a fourth title against unknown quantity Burundi.
Group D is the pick of the draw for the Africa Cup of Nations, with Morocco, Ivory Coast, South Africa and Namibia set to meet in the pool.
A 1-1 draw with Gabon secured Burundi the point they needed to reach the Africa Cup of Nations for the first time in their history.