Giannis Antetokounmpo scored 36 points, while Khris Middleton was crucial down the stretch as the Milwaukee Bucks clinched.
The Los Angeles Lakers suffered a third straight defeat as LeBron James exiting the game nursing an ankle worry.
Oklahoma City Thunder were on the wrong end of the Indiana Pacers' record-breaking efforts, leaving them with nowhere to hide.
The Indiana Pacers showed no mercy against the Oklahoma City Thunder, while the Denver Nuggets took down the Los Angeles Clippers.
Kevin Porter Jr. had 50 points and 11 assists to lead the Houston Rockets to a wild victory over the Milwaukee Bucks.
The Brooklyn Nets sealed their postseason spot, while the Portland Trail Blazers put on a shooting display against the Indiana Pacers.
Ben Simmons made a big impact on his return to NBA action with the Philadelphia 76ers and admitted: "I missed being with the fellas."
The Utah Jazz went down to the Minnesota Timberwolves, while the New York Knicks and Washington Wizards crashed back down to earth.
Stephen Curry starred again for the Golden State Warriors on Friday, while Russell Westbrook had another triple-double.
The Philadelphia 76ers and the Brooklyn Nets both lost on Wednesday although Joel Embiid almost produced heroics on the buzzer.