Wales will be out to make it three wins from three in the 2021 Six Nations when they face England on a milestone occasion for George North.
After defeat to Scotland in the opening round, Eddie Jones has drafted in some familiar faces to take on Italy.
A dominant Sale Sharks performance was marred by an injury to Manu Tuilagi, while Northampton lost Courtney Lawes.
England prop Joe Marler has received a 10-week suspension after a flashpoint involving Alun Wyn Jones in Saturday's clash with Wales.
Joe Marler and Courtney Lawes will face a disciplinary hearing on Thursday following incidents in the defeat of Wales.
England must show they have a mature mentality if they are to defeat Scotland and clinch the Calcutta Cup, says Courtney Lawes.
Brodie Retallick referred to Courtney Lawes as Michael Laws when England toured New Zealand in 2014.
Eddie Jones has made a couple of surprise team selections for Saturday's Rugby World Cup quarter-final against Australia.
Courtney Lawes will be sidelined for at least four weeks, ruling him out of England's Six Nations clashes with Italy and Scotland.