Sevilla will return to the Champions League after Villarreal's hopes ended with a 2-1 loss at home to Real Sociedad on Monday.
Antoine Griezmann ended his wait for another goal and Barcelona head coach Quique Setien was happy with the forward.
Trailing rivals Real Madrid in LaLiga, Gerard Pique wants Barcelona to keep pushing.
Barcelona celebrated a milestone thanks to teenage sensation Ansu Fati on Sunday.
Champions Barcelona showed they will not give up their title without a fight, outclassing Villarreal in a comfortable win.
Due to an issue with his right hip, Junior Firpo will not feature for Barcelona against Villarreal.
Quique Setien's future as Barcelona head coach has been called into question but the Spaniard is taking no notice of the speculation.
Samuel Umtiti is to undergo "conservative treatment" on his left knee, but Barcelona have not stated how long he may be out of action.
Not since May 2017 had Bruno Soriano played a game for boyhood club Villarreal but the 36-year-old returned to action on Monday.
Karl Toko Ekambi has joined Lyon from Villarreal on a permanent deal that could rise to €15.5million.