Valencia scored four second-half goals to beat Lille 4-1 in an entertaining Champions League clash at the Mestalla.
Marco Reus can make history for Borussia Dortmund as the German club host Inter in Tuesday's Champions League matches.
Zlatan Ibrahimovic has been linked with a sensational return to Old Trafford in January.
A late Jonathan Ikone goal cost Valencia two Champions League points in Lille, leaving head coach Albert Celades infuriated.
Jonathan Ikone scored in second-half stoppage-time to rescue a 1-1 draw for Lille against 10-man Valencia.
Barcelona, Chelsea and Liverpool all feature in the best Opta facts ahead of Wednesday's batch of Champions League matches.
London could be calling for former Chelsea and Manchester United boss Jose Mourinho amid uncertainty at Tottenham.
After suffering a nasty injury in Tottenham's defeat to Brighton and Hove Albion, Hugo Lloris has been replaced in the France squad.
Tammy Abraham claimed his allegiance to England was not confirmed after scoring his first Champions League goal for Chelsea.
Tammy Abraham looks to have a strong case for England selection after scoring a first Champions League goal for Chelsea.