Daley Blind, Steven Berghuis and Donyell Malen are back under new Netherlands coach Frank de Boer, while Teun Koopmeiners could debut.
Having undergone a series of examinations following his collapse in a friendly, Daley Blind has returned to training with Ajax.
Mohamed Ihattaren and Perr Schuurs are among the new faces in the Netherlands squad, while Tim Krul and Leroy Fer are recalled.
Petahanan Ajax, Daley Blind, meredakan kebimbangan mengenai tahap kecergasannya dengan menegaskan bahawa dia "OK dan berasa sihat" selepas hampir kehilangan nyawa.
Daley Blind, 30, used social media to thank everyone for their support after a scare during Tuesday's friendly win over Hertha Berlin.
Daley Blind will undergo tests on Wednesday after a health scare during an Ajax friendly.
Daley Blind insists he is "feeling good" and is "trying to come back as soon as possible" after he was diagnosed with a heart problem.
Chelsea conceded three first-half goals in a Champions League game for the first time but battled back against nine-man Ajax to draw 4-4.
Chelsea have turned to youth since Frank Lampard took charge and Ajax boss Erik ten Hag can see similarities with his own side.
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