West Indies claimed five wickets in the final session of Saturday's play as England ended eight down with a lead of 170 runs.
Half centuries from Kraigg Brathwaite and Shane Dowrich put West Indies in a commanding position after three days in Southampton.
Jason Holder reflected on his memorable display in Southampton, where the West Indies captain wreaked havoc against England on Thursday.
Career-best figures of 6-42 from Jason Holder restricted England to 204, with West Indies finishing the second day on 57-1.
Jason Holder has been impressed with how West Indies have prepared to face England, who will have Ben Stokes in charge at Southampton.
Ben Stokes conceded he would be "stupid" not to take advice from his team-mates when he leads England for the first time.
Dom Sibely, who is relishing the chance to build on some impressive England displays, has backed Ben Stokes to excel as a stand-in captain.
As Ben Stokes prepares to stand in for the absent Joe Root, England get the chance to potentially get a glimpse of the future.
Jonny Bairstow and Moeen Ali have missed out on England's squad for the first Test against West Indies in Southampton next week.
England all-rounder Ben Stokes will fill in for Joe Root as captain and Chris Silverwood is confident he can excel in the role.