Matt Toomua scored 23 points in Leicester Tigers' win over Harlequins, while Gloucester were beaten at lowly Worcester Warriors.
It was a memorable day for Worcester Warriors at Exeter Chiefs, as Saracens neared the top of the Premiership.
A stadium swap did not deter Brive, who booked their place in the European Challenge Cup quarter-finals by beating Worcester Warriors.
A draw against Worcester Warriors was enough for Connacht to book their place in the Challenge Cup quarter-finals.
Leicester Tigers and Northampton Saints both ended winless runs as Sale Sharks beat 14-man Harlequins in a Premiership thriller.
Saracens slipped to a rare home Premiership defeat as leaders Exeter Chiefs showed their steel at Allianz Park.
The Premiership has a new leader after Exeter Chiefs capitalised on a defeat for Saracens with victory over Harlequins.
There were Premiership wins for Wasps, Saracens and Harlequins on Saturday, even though the latter conceded six tries to Worcester Warriors.
Bordeaux-Begles gave up a commanding lead to lose at home to Newcastle Falcons in the Challenge Cup on Saturday.
European Challenge Cup holders Stade Francais went down to a shock defeat against debutants Krasny Yar in Siberia on Saturday.