Anthony Watson and Luke Cowan-Dickie have returned to the England squad for the Autumn Nations Cup clash with Wales on Saturday after recovering from injury.
Bath back Watson sustained an ankle injury in the Six Nations win over Italy last month, while Exeter Chiefs hooker Cowan-Dickie is back to full fitness after undergoing knee surgery.
Wasps fly-half Jacob Umaga and Northampton full-back George Furbank, meanwhile, have withdrawn from the 35-man squad due to injury.
Eddie Jones' side beat Ireland 18-7 on Sunday and another victory in Llanelli on Saturday will see them compete against the winners of Group B on December 6 to decide who lifts the trophy.
Backs: Joe Cokanasiga, Elliot Daly, Owen Farrell (captain), George Ford, Jonathan Joseph, Ollie Lawrence, Max Malins, Jonny May, Alex Mitchell, Dan Robson, Henry Slade, Ollie Thorley, Anthony Watson, Ben Youngs.
Forwards: Luke Cowan-Dickie, Tom Curry, Tom Dunn, Ben Earl, Charlie Ewels, Ellis Genge, Jamie George, Jonny Hill, Maro Itoje, Joe Launchbury, Lewis Ludlam, Joe Marler, Beno Obano, David Ribbans, Kyle Sinckler, Will Stuart, Sam Underhill, Billy Vunipola, Mako Vunipola, Harry Williams, Jack Willis.