Wales need a victory against France in Paris to reclaim the Six Nations crown, and complete a Grand Slam in the process.
Wayne Pivac's team have enjoyed a sensational turnaround in fortunes this year and last week's 48-7 thrashing of lowly Italy made it four wins from four.
With France subsequently losing to England at Twickenham, Wales will wrap up the title with a win on Saturday, while even a losing bonus point could be enough, though that may still leave the door open for Les Bleus to snatch glory should they win their postponed fixture against Scotland.
England are well out of the race, but their captain Owen Farrell is eyeing up a points landmark when the 2020 champions take on Ireland in Dublin.
Scotland, meanwhile, round off what will ultimately go down as a frustrating campaign against Italy.
We use Opta data to preview the round-five, Super Saturday encounters.
SCOTLAND V ITALY
Scotland have won their last five Six Nations games against Italy – the previous 10 clashes between the sides had seen them share five wins each.
Italy have lost 52 of 54 away games in the Six Nations, with their only two victories on the road coming in Scotland in 2007 and 2015.
That victory at Murrayfield in 2015 was Italy's last in the competition. Their losing streak now stands at 31 games, and they will pick up the wooden spoon for the 16th time in Six Nations history.
ONES TO WATCH
Scotland have the best tackle success rate (92 per cent) of any side in this year's competition. Hamish Watson leads the way in that regard, completing all 44 of his attempted tackles – he has made 133 consecutive tackles in the tournament without missing one, the second-longest such run in Six Nations history, behind Lionel Nallet's 154 for France.
Italy's Sebastian Negri has made 127 post-contact metres in the 2021 Six Nations, the most of any forward in the championship.
IRELAND V ENGLAND
England have won their last two meetings with Ireland in the Six Nations and could win three in a row against them for only the second time, after doing so between 2012 and 2014.
Ireland lost to France in their last home game, only once before have they suffered defeat in back-to-back home games in the Six Nations – in 2010 versus Scotland at Croke Park and 2011 versus France at the Aviva Stadium.
Jones' England have won their last four Tests against Ireland, preventing them from scoring any first-half points in their last two meetings and scoring an average of 4.3 tries per game in that run.
ONES TO WATCH
CJ Stander announced his retirement this week, with the 31-year-old set to hang up his boots at the end of the season. This will be his final appearance for Ireland, having won his 50th cap in the 27-24 win over Scotland in round four.
Owen Farrell, son of Ireland coach Andy, is the top scorer in the Six Nations this year (44) and is just six points away from 500 in the championship. Only Ronan O'Gara (557) has reached that milestone exclusively in the Six Nations (since 2000).
FRANCE V WALES
Wales are bidding to win a sixth Six Nations title (since 2000), only England (seven) have won the championship more often. If they win this match it would be their fifth
Grand Slam – no other side has more than three.
Recent history is on Wales' side heading to the Stade de France. They have won three of their last four away games against Les Bleus in the Six Nations (L1), triumphing in their last trip to Paris (24-19 in 2019) despite trailing by 16 points at half-time – the biggest comeback for a team in the competition.
Indeed, pre-tournament favourites France have won only two of their last nine Six Nations games against Wales (L7) after winning nine of the previous 12 (L3).
ONES TO WATCH
Antoine Dupont already has four try assists in this Six Nations, only five players have ever recorded more in an edition of the championship, with Frederic Michalak
(seven in 2006) the only Frenchman to do so.
Louis Rees-Zammit is the joint top try scorer in the 2021 Six Nations (four, level with England's Anthony Watson). Shane Williams (six in 2008) is the only Welsh player to score more than four in an edition of the tournament.