England prop Mako Vunipola will miss the crunch Six Nations clash with Ireland at Twickenham on Sunday for family reasons.
Vunipola made his first appearance of the tournament in the victory over Scotland but will not face Ireland after travelling to Tonga.
Ellis Genge could be handed a start after scoring the winning try in the Calcutta Cup clash at Murrayfield. Alternatively, Joe Marler could come back into the side, with the uncapped Beno Obano offering another option.
Fit-again centres Manu Tuilagi and Henry Slade were among the 33 names included by Eddie Jones for England's first home match of the tournament.
The Rugby World Cup runners-up were beaten by France in their opening match before edging out Scotland in brutal conditions in Edinburgh, while Ireland have won two out of two.
England squad:
Forwards: Luke Cowan-Dickie, Tom Curry, Tom Dunn, Ben Earl, Charlie Ewels, Ellis Genge, Jamie George, Maro Itoje, George Kruis, Joe Launchbury, Courtney Lawes, Lewis Ludlam, Joe Marler, Beno Obano, Kyle Sinckler, Will Stuart, Sam Underhill, Harry Williams.
Backs: Elliot Daly, Ollie Devoto, Fraser Dingwall, Owen Farrell, George Ford, George Furbank, Willi Heinz, Jonathan Joseph, Jonny May, Henry Slade, Ollie Thorley, Manu Tuilagi, Jacob Umaga, Ben Youngs.
