Sergio Ramos has not been named in Real Madrid's squad for their LaLiga match Celta Vigo on Saturday.
The Madrid captain did not train on Friday and, according to Marca, is struggling with a stomach issue.
Ramos, the only unexpected absentee from a 23-man group, has scored twice in 13 league appearances this season.
The centre-back has contributed to five clean sheets, averaging 1.1 tackles, 2.8 clearances, 1.5 interceptions and 0.3 blocks per 90 minutes.
He has made only a single error leading to a shot and received three yellow cards.
Madrid will have to adapt to the absence of the talismanic Ramos, having won just one of the three prior league games he has missed this term.
However, the defending champions are unbeaten in 12 against eighth-placed Celta in LaLiga.