Paris Saint-Germain will visit either Guingamp or Caen when they begin their Coupe de France defence in the round of 64.
PSG won the competition last season as former head coach Thomas Tuchel masterminded a treble triumph, beating Saint-Etienne 1-0 in the final.
That successful campaign started away to sixth-tier Linas-Montlhery and Mauricio Pochettino's PSG will be on the road again after being drawn against Guingamp or Caen.
The Ligue 2 sides are set to face one another on January 20 for the right to host the French champions in February.
PSG have won the trophy a record 13 times, including five of the past six editions.
Saint-Etienne are also away - to Nancy or Sochaux - but Ligue 1 leaders Lyon will welcome Chateauroux or Ajaccio to the Groupama Stadium.
Marseille will visit Troyes or Auxerre, while Monaco are heading for Clermont or Grenoble.
Lille face Ligue 1 opposition in the form of struggling Dijon, and fourth visit seventh as Rennes go to Angers.