Ole Gunnar Solskjaer is confident Manchester United can halt Manchester City's astonishing 21-game winning run if they are at their very best at the Etihad Stadium on Sunday.
City look certain to regain the title and remain in the hunt for an unprecedented quadruple following a run of 28 matches without defeat.
Third-placed United trail their neighbours by 14 points ahead of the derby and really need a repeat of their victories at the home of their rivals in the two previous visits if they are to have any chance of being crowned champions.
United boss Solskjaer has full faith that this side can stop City's record-breaking streak.
He told the club's official website: "We have to be the best possible Man United, no matter who plays on the other side.
"When we're the best possible Man United, I back my team in any game against any team. That's the key. Of course, they'll cause us problems, but we have to find the solution and try to give them other problems to worry about."
Solskjaer says the Red Devils can have no complaints about such a demanding schedule this season.
The former Norway striker added: "It's a challenge for the team. The most successful Man United teams over the years always used to have this.
"Maybe once in a while we'd get a midweek off, but we haven't and we haven't had any easy cup draws either to rest players. The only way to improve, get better and get used to this is to go through it.
"The players are getting more and more robust, physically and mentally, and I've been impressed by them and they recover [from games] really well.
"Of course, once in a while you don't really hit your best form, that's natural and we understand that.
"Everyone goes onto the pitch to do their best and now it's a derby and of course everyone is going to be fired up and any mental or physical fatigue is not going to come into play, that's for sure."