Everton ended over 21 years of hurt as they beat Liverpool at Anfield for the first time this century in Saturday's headline Premier League game.
That triumph over defending champions Liverpool came after Chelsea had drawn with Southampton, while Burnley and West Brom also shared the spoils at Turf Moor.
In the day's other game, Fulham boosted their survival bid with a 1-0 victory over lowly Sheffield United.
Using Opta data, we look at key facts from the four Premier League games.
LIVERPOOL 0-2 EVERTON: RICHARLISON AND SIGURDSSON SEAL DERBY BRAGGING RIGHTS
Everton picked up their first win over Liverpool in 24 meetings in all competitions (D12 L11) – ending what was Liverpool's longest ever unbeaten run against a single opponent.
Richarlison's third-minute goal was teed up by James Rodriguez, who has provided more assists in all competitions this season than any other player for Everton (eight). It was the Toffees' second-fastest Premier League goal scored against Liverpool, behind only Olivier Dacourt's first-minute strike in April 1999.
Brazil forward Richarlison became only the third Everton player to score in successive Premier League appearances at Anfield for the club, after Tim Cahill in March 2006 and Kevin Campbell in October 2000.
Liverpool dominated possession, with Jordan Pickford making six saves, including standout stops from Jordan Henderson and Mohamed Salah.
Meanwhile, Liverpool have lost four consecutive home league games for only the second time, last doing so back in December 1923 – when they were also defending top-flight champions. The result ended Everton's run of 23 winless Anfield clashes with Liverpool without a win in all competitions (D10 L13) since a 1-0 victory in September 1999.
Reds boss Jurgen Klopp has suffered four consecutive league defeats for the first time since November 2014 when he was in charge at Borussia Dortmund, while he has lost four in a row at home in league competition for the very first time in his managerial career.
Gylfi Sigurdsson's penalty settled the contest, and the Iceland playmaker has now scored five away goals against Liverpool in all competitions – more than he has away at any other opponent in his career in England.
SOUTHAMPTON 1-1 CHELSEA: SAINTS HALT LOSING STREAK AS TUCHEL STALLS
Southampton ended a run of six successive Premier League defeats, the club's worst losing run in their league history, as they earned a point against Chelsea.
Blues boss Thomas Tuchel became the 16th manager in Premier League history to avoid defeat in his first six games in the competition (W4 D2) and the first since Maurizio Sarri in September 2018, also with Chelsea. However, he did see his side's four-match winning streak come to an end.
Southampton took the lead through Takumi Minamino, who became the first opposition player to score against Tuchel's Chelsea in all competitions, ending a run of 572 minutes without such a goal for the German manager (Antonio Rudiger scored an own goal against Sheffield United).
The draw means Saints have lost 18 points from leading positions in the Premier League this season, more than any other side.
Mason Mount's penalty pulled Chelsea level – Southampton have now conceded five goals from the spot this term. Only in 1993-94 and 2016-17 (both six) did Saints concede more goals from the spot in a Premier League campaign.
Mount became the 25th different player to score a penalty for Chelsea in the Premier League, with the Blues having more penalty scorers than any other team in the competition's history.
FULHAM 1-0 SHEFFIELD UNITED: LOOKMAN LIFTS COTTAGERS
Fulham's resurgence continued as they picked up just their second victory in 14 Premier League home games (W2 D4 L8) and first since beating West Brom in November.
Scott Parker's team have now taken seven points from their last three league matches and are just three points from safety.
Lowly Sheffield United, meanwhile, missed out on the chance to move off the bottom, and the Blades have only won two of their 28 Premier League games in London (D8 L18), winning at Chelsea in October 1992 (2-1) and Crystal Palace in February 2020 (1-0).
Ademola Lookman scored the winner, and the on-loan winger has been directly involved in more Premier League goals than any other Fulham player this season (four goals, three assists).
BURNLEY 0-0 WEST BROM: NO GIVE AT TURF MOOR
A clean sheet finally arrived for West Brom, as they registered their first in 15 Premier League games since a 1-0 win at home to Sheffield United in November.
The Baggies had the best chances to snatch a much-needed win, but ultimately Sam Allardyce – whose side lost Semi Ajayi to a red card in the first half – had to settle for a draw.
The last two occasions West Brom have received a red card and avoided defeat in a Premier League game have both been against Burnley (they won 1-0 in August 2017).
Burnley have won just one of their eight Premier League meetings with West Brom (D4 L3), earning a 2-1 success at the Hawthorns in March 2018.
Since the start of last season, Burnley have kept 24 clean sheets in the Premier League – only Manchester City (31) have had more in this period.