Mason Greenwood replaces the injured Anthony Martial in the Manchester United team as Jose Mourinho returns to Old Trafford for the first time since his sacking.
Martial was substituted towards the end of United's last match, a 2-2 Premier League draw with Aston Villa, and Ole Gunnar Solskjaer told MUTV the France forward could be out for "a little while".
Taking Martial's place in the United attack is 18-year-old striker Greenwood, who starts a Premier League game for the first time this season, while Scott McTominay is fit to come into midfield.
Juan Mata, Andreas Pereira and Brandon Williams drop out of the team that started against Villa, with Ashley Young, McTominay and Jesse Lingard drafted into the XI.
Menwhile, Mourinho's selection sees Harry Winks return to the Tottenham midfield at the expense of Tanguy Ndombele, who drops to the bench.
Eric Dier has also been left out following the win over Bournemouth at home, Lucas Moura coming into the team instead.