Kawhi Leonard will sit out the Raptors' clash with the 76ers on Saturday, head coach Nick Nurse has confirmed.

The Toronto star poured in 37 points in a 126-110 victory over the Cavaliers Friday night, equalling his best total for a game this season as the Eastern Conference leaders moved to 25-9.

Leonard, acquired from the Spurs in an off-season trade, played just nine games last season due to a nagging quadriceps injury and he has yet to play in back-to-back games this season.

The Raptors will not deviate from that plan against Philadelphia, even though Kyle Lowry, Danny Green and Serge Ibaka could again be missing for the franchise with the NBA's best record.

"Kawhi will not play," Nurse told reporters after the win against the Cavs.

"There's a chance [the injury situation] will be [better].

"There's a chance that both Danny and Kyle could play tomorrow but they're not great chances."

Leonard credited his teammates for stepping up in the absence of other key figures against Cleveland.

"It was a good win, our lineup's been switching up a lot with guys being injured," he told Sportsnet.

"The next man came in and played well. We were moving the ball great and we got open looks."