Mark Wood has been ruled out of England's first Test in Pakistan due to a hip injury.
The fast bowler sustained another injury setback during England's successful T20 World Cup campaign, missing the semi-final and final in Australia.
Wood sat out a training camp in Abu Dhabi last week in the hope of making the first contest of a three-match series against Babar Azam's side, which begins in Rawalpindi on Thursday.
Head coach Brendon McCullum said: "Mark's not going to make the first Test squad unfortunately because of his injury.
"We expect him to be ready for the second Test and otherwise we've got a full squad to pick from."
The 32-year-old quick has played 26 Tests for England, taking 82 wickets at an average of 31.91.
England also have James Anderson, Ollie Robinson, Jamie Overton in their squad, while captain Ben Stokes is another seam option.
England's other pace options for the first Test include James Anderson, Ollie Robinson, Jamie Overton and captain Ben Stokes, while Jack Leach is the main spin option.
Leg-spinning all-rounder Renan Ahmed could become the youngest man to play a Test for England at the age of 18 if he is given the nod.
Rawalpindi, Pakistan pic.twitter.com/ngZH1fC30C— England Cricket (@englandcricket) November 28, 2022