James Anderson and Stuart Broad were the only members of the England squad who were born when the tourists last won an Ashes Test at the Gabba.
The hostile iconic Brisbane venue has been such a fortress for Australia that you have to go back to November 1986 for their previous Test defeat to England at the ground where the 2021-22 series starts on Wednesday.
Yet India consigned Australia to a first Gabba loss in the longest format for over 32 years in January and England captain Joe Root is backing his side to end the hoodoo, despite a lack of match practice due to rain.
The world's number one Test batter said: "[Victory] would absolutely set us up for the rest of the series and it's a great opportunity.
"This group of players, not that long ago, went to Cape Town where we've not won a Test for a long period of time and off the back of a performance there won the series.
"I feel like we have been able to do that around the world and this is an opportunity to do that here. Obviously conditions are slightly different to home, at this venue in particular with that extra bit of bounce, but we have prepared as well as we can for that. If we manage that well we should give a really good account of ourselves and start well."
Ben Stokes' return gives England a massive lift as they attempt to wrestle back the urn, though they won't have the usual level of backing from the Barmy Army as usual due to coronavirus travel restrictions.
The tourists were thrashed 4-0 in their last Ashes series Down Under in 2017-18 after the humiliation of a 2013-14 whitewash, so it is almost 10 years since their last Test win in Australia.
Stats Perform looks at some of the key factors that will decide whether they can make it a miserable start to Pat Cummins' reign as Australia Test captain.
Stoking the fires
Stokes has not played for his country since July, but declared himself fit to face Australia after taking a break to prioritise his mental well-being and fully recover from a fractured finger.
The all-rounder was England's player of the series in an Ashes series two years ago that ended in a 2-2 draw, scoring 441 runs at an average of 55.12 and producing one of the great innings at Headingley to pull off an unlikely victory.
Vice-captain Stokes' return should add strength to the middle order they have been lacking and Root will be hoping he can do some damage in short, sharp bursts with the ball.
Root must keep racking up the runs
It has been an incredible 2021 for Root, who has scored six Test centuries - including one double-hundred in Sri Lanka and another in India.
The skipper said this tour will define his captaincy and England will need him to keep racking up the runs if they are to return home with a surprise series win.
Only five batsmen have scored more Test centuries in a year than Root's tally, with Mohammad Yousuf holding the record with a staggering nine in 2006.
Lack of pace potency?
Not for the first time in Ashes, a lack of pace could be a big issue for England and how they would love to have a fit Jofra Archer firing.
Australian Troy Cooley was brought into the touring party as a consultant pace bowling coach and there is no doubting the quality in the England attack, led by James Anderson and Stuart Broad.
Broad tormented Warner in the 2019 series, but the opener could be much more difficult to dismiss on home soil with a Kookaburra ball and returned to form in Australia's recent T20 World Cup triumph.
Mark Wood is capable of doing damage but it remains to be seen how many Tests the injury-prone quick can play. Ollie Robinson could make a big impact in his first Ashes series and Chris Woakes can hit the sort of lengths to trouble batters in Australia.