Los Angeles Lakers superstar LeBron James has been cleared to play by the NBA after returning two negative COVID-19 tests.

James entered the NBA's health and safety protocols on Tuesday, sitting out the 117-92 win over the Sacramento Kings due to a positive coronavirus test.

But James cleared the league's COVID protocols after additional testing confirmed the four-time champion and MVP was not a positive case.

"Following two negative PCR tests conducted more than 24 hours apart, Los Angeles Lakers forward LeBron James has cleared the NBA's Health and Safety Protocols," the league said in a statement on Thursday.

"James was originally placed in the Protocols on Tuesday, November 30 after a series of tests delivered conflicting results, including an initial positive test that was collected on November 29. Additional testing confirmed that he is not a positive case.

"In accordance with the Protocols, and the consistent testing practice that has been in place since the 2019-20 Season Restart in Orlando, the sample that produced the initial positive test was re-run twice and returned one negative and one positive result on two different PCR instruments.

"As a result, James underwent additional testing on November 30, with one test returning a negative result and a second test resulting in a clinically inconclusive result."

It is a boost for the Lakers (12-11) ahead of Friday's showdown with crosstown rivals the Los Angeles Clippers (11-11).

James has been averaging 25.8 points, 6.8 assists and 5.2 rebounds per game for the Lakers, while shooting 48.4 per cent from the field and 34.4 from three-point range.