Barcelona head coach Ronald Koeman is under immense pressure and needs a convincing win over Dynamo Kiev, having failed to earn any points from the first two Champions League games of the campaign.
Manchester United manager Ole Gunnar Solskjaer is also in great need of a positive result, having won just two of his past seven games across all competitions, losing four.
Bayern Munich and Chelsea seem set for comfortable victories, however, with Blues boss Thomas Tuchel targeting the joint-best defensive record after 10 games with a club in the competition.
Read on for more as Stats Perform looks at the key Opta facts ahead of Wednesday's Champions League action.
Barcelona v Dynamo Kiev: Can Koeman stop the rot?
Koeman will be desperate to prevent his Champions League record at Barcelona from getting any worse after successive 3-0 defeats to Bayern Munich and Benfica in which the Blaugrana recorded a collective total of one shot on target, the least of any team in the competition.
Despite only taking charge of four per cent of Barcelona’s home Champions League matches (5/131), 25 per cent of their total home defeats in the competition have come under the Dutchman (3/12), who is the only Blaugrana manager to lose more than twice at home in the tournament.
Ansu Fati is perhaps Koeman's best chance of securing a positive result. The 18-year-old forward has been directly involved in three goals in two Champions League starts at Camp Nou (one goal and two assists), including an assist for Gerard Pique's goal in the 2-1 win against Dynamo Kyiv last year.
Benfica v Bayern Munich: Lewandowski-led Bavarians expect to stay unbeaten on the road
Bayern's record of eight European Cup/Champions League games unbeaten against Benfica is the joint-most by a team against an opponent since the tournament began in 1955.
With the Bavarian giants also on a record 19-match unbeaten run away from home in the competition (W15 D4), Julian Nagelsmann's side will feel confident of success in Portugal.
Furthermore, striker Robert Lewandowski - who has scored over a third of their 54 goals from that run (19 - 35 per cent) - has also netted five times in just six Champions League games against Portuguese opponents, including three against Benfica. No player has ever scored more times against sides from Portugal in the competition.
Chelsea v Malmo: Clean-sheet chasing Blues Luk-ing for big win
Both of Chelsea's Champions League games this season have ended 1-0 - a win over Zenit and a loss to Juventus - but the Blues will be hoping for a more convincing scoreline as they host a Malmo side that have already conceded seven goals (the second-most in the tournament) and have lost their last five games in the competition by an aggregate score of 0-24, losing by three or more goals on each occasion.
Chelsea centre-forward Romelu Lukaku, in particular, will be relishing the opportunity to boost his already impressive tally of 14 goals in 18 appearances in European competition since the start of the 2019-20 season. In this period, the only two players who have scored more non-penalty goals than Lukaku (12) across the Champions League and Europa League are Lewandowski (19) and Erling Haaland (18).
Tuchel will also be hoping for a seventh clean sheet in his 10th Champions League game in charge of Chelsea. The Blues have only conceded three goals under the German so far, which would be the joint-fewest through a manager’s first 10 games of a club in the competition (along with Fabio Capello at AC Milan and Jose Mourinho at Real Madrid).
Manchester United v Atalanta: Ronaldo and Fernandes to rescue Solskjaer?
Manchester United boss Solskjaer comes into this game under pressure after a 4-2 loss to Leicester City in the Premier League. The Red Devils have lost 58 per cent of Champions League games (7/12) under the Norwegian - the highest percentage of defeats by any manager to have taken charge of an English side on 10 or more occasions in the competition.
Solskjaer will be relying on his dynamic Portuguese duo to earn a much-needed win at Old Trafford. Cristiano Ronaldo has scored 18 goals in 23 Champions League appearances against Italian sides, while Bruno Fernandes' four goals and three assists is the most direct contributions to a goal from any midfielder since his debut in the competition for United.
Atalanta are no pushovers, however. The Serie A side have only lost one of their last seven away games in the Champions League, winning five and drawing the other, and have won three of their six UEFA European matches against English opponents (D1 L2).
Zenit v Juventus
0 – Juventus have never lost in eight previous encounters with Russian sides in European competition (W7 D1), scoring 18 times and only conceding three, although their only failure to win came away at Zenit in November 2008.
4 – Juventus have won their last four games in the group stage of the Champions League without conceding a single goal, with two of these coming away from home – 3-0 against Barcelona in December 2020 and 3-0 against Malmo in September 2021.
Young Boys v Villarreal
8 – Villarreal have lost eight of their last nine games in the Champions League (D1), conceding at least two goals in all nine outings in this run. They will be looking for their first win in the competition since March 2009, when they won 2-1 against Panathinaikos under Manuel Pellegrini.
3 – Young Boys are unbeaten in their last three home games in the Champions League (W2 D1), and could equal their longest run without defeat on home soil in the European Cup/Champions League – a run of four games between 1957 and 1959.
Salzburg v Wolfsburg
21 – In Salzburg’s last four UEFA European competition meetings with German opponents, there have been 21 goals scored (six for, 15 against) – last season’s Champions League games against Bayern Munich alone saw 12 scored (2-6 home defeat, 3-1 away defeat).
4 – Karim Adeyemi has won four penalties for RB Salzburg in the Champions League this season. Since 2003-04 (as far back as we have this data), no player has ever won more than four in a single season in the competition.
Lille v Sevilla
32 – The average age of Sevilla’s starting XI in the Champions League this season is 29 years and 200 days; the oldest of any of the 32 sides. Sevilla have handed starts to five different players aged 30 or older in the competition this season (Jesus Navas, Fernando, Papu Gomez, Ivan Rakitic and Yassine Bounou), with only Malmo (six) having more.
15 – Lille have won just 15 per cent of their home games in the Champions League to date (3/20) – among teams to have played 20 or more home games in the competition, only Romanian side FC Steaua Bucharest have a worse win percentage (9.5 per cent - 2/21).
7 - @SevillaFC_ENG are unbeaten in their last seven away games in this competition (W3 D4); their longest ever unbeaten run away from home in the European Cup/ @ChampionsLeague . Energy. pic.twitter.com/EZg8csLjZG— OptaJose (@OptaJose) September 29, 2021