Arsenal could welcome back Alexandre Lacazette at Sheffield United following a seven-week lay-off with injury.
Nicolas Pepe is yet to justify his hefty price tag at Arsenal and Unai Emery is working closely with the former Lille star.
Arsenal led 2-0 at the interval but had to settle for a draw against struggling Watford on Sunday.
Arsenal's Alexandre Lacazette has scored two Premier League goals this term but the France forward is set for a short injury lay-off.
Opta Data Diary: Liverpool set a new club record of consecutive league victories while Sergio Aguero neared a personal milestone.
Arsenal fought back from two goals down to rescue a 2-2 draw in the north London derby against bitter rivals Tottenham.
Arsenal boss Unai Emery has suggested Pierre-Emerick Aubameyang, Alexandre Lacazette and Nicolas Pepe could all start against Tottenham.
Pierre-Emerick Aubameyang and Alexandre Lacazette scored either side of Ashley Barnes' goal to give Arsenal a hard-earned home win.
Unai Emery has made three changes to his Arsenal side, including David Luiz in the starting XI for the first time.
Unai Emery says Arsenal are "working on" contract extensions for two key attackers.