Jose Mourinho's perfect record as Tottenham boss is over after a defeat at Manchester United while Liverpool won the Merseyside derby.
Manchester City have a favourable draw in the FA Cup third round, but there are difficult trips for Everton and Manchester United.
Manchester United host obliging opposition in Aston Villa as Burnley try to equal a record - have a go at our weekly quiz, powered by Opta.
Sofiane Boufal is a doubt for Southampton's crunch Watford clash, having injured his toe running into his kitchen table.
Arsenal head coach Unai Emery is under growing pressure after a six-match winless run but is confident he has the backing of his bosses.
Arsenal have failed to win their past five Premier League matches and Pierre-Emerick Aubameyang called for efforts to be redoubled.
There were five away wins in the 3pm Premier League kick-offs on a day when Jose Mourinho took charge of Tottenham for the first time.
Arsenal are five Premier League games without a win after Alexandre Lacazette scored twice in a 2-2 home draw with Southampton.
Matchday 13 in the Premier League sees a London derby and Manchester City v Chelsea, so why not test yourself with our Opta-powered quiz?
Unai Emery has suffered a blow to his hopes of turning Arsenal's form around, learning he will be without Dani Ceballos for the next month.