Lucas Hernandez has missed Bayern Munich's last two matches with a knee injury and has been blocked by his club from linking up with France.
David Alaba, who initially appeared to have avoided serious injury, is set for a spell on the sidelines with a cracked rib.
Neither David Alaba nor Lucas Hernandez - two left-sided defensive options - will be available as Bayern Munich face Hoffenheim.
David Alaba and Jerome Boateng could yet feature for Bayern Munich against Hoffenheim in the Bundesliga this weekend.
Bayern Munich head coach Niko Kovac will be without midfielder Ivan Perisic for Saturday's Bundesliga clash at Paderborn because of illness.
The left-back has not played for Bayern since last month, but Niko Kovac expects David Alaba to be fit to face Tottenham.
Niko Kovac has given an update on how long Bayern Munich expect to be without left-back David Alaba.
Bayern Munich have confirmed David Alaba tore a muscle before the Bundesliga draw against RB Leipzig.
Bayern Munich claimed their first home win of the season as they came from behind to cruise to a 6-1 Bundesliga victory over Mainz.
Barcelona's rumoured interest is an "honour" for David Alaba, but Bayern Munich can rest easy about the left-back's level of commitment.