Thursday's 1-1 draw away to Cerro Porteno was enough for River Plate to reach the semi-finals 3-1 on aggregate.
Gabigol scored to earn Flamengo a 1-1 draw away to Brazilian rivals Internacional and a 3-1 aggregate victory.
Boca Juniors and Flamengo closed in on the last four in the Copa Libertadores.
Daniele De Rossi had his first proper taste of life at Boca Juniors as he stepped out onto the famous La Bombonera turf in Buenos Aires.
On debut for Boca Juniors, Daniele De Rossi opened the scoring against Almagro in the Copa Argentina.
Nahitan Nandez completed his long-expected move to Cagliari, who reportedly paid Boca Juniors €18million for his signature.
Cristian Pavon, previously linked with a huge transfer to Europe, has joined Zlatan Ibrahimovic at LA Galaxy in MLS.
Marseille have secured just their second signing of the transfer window, with Dario Benedetto joining from Boca Juniors.
Boca Juniors were too good for Athletico Paranaense in the last 16 of the Copa Libertadores.
Boca Juniors presented Daniele De Rossi on Monday and the World Cup winner saluted the passion of the club's supporters.