River Plate and Lanus overcame Guarani and The Strongest in the Copa Libertadores round of 16 on Tuesday.
2015 champions River Plate triumphed 2-0 at Paraguayan hosts Guarani in the first knockout round of the Copa Libertadores.
With a last-16 spot on the line, Gremio made no mistake in the Copa Libertadores.
Despite being held to a draw at home, Godoy Cruz advanced to the Copa Libertadores knockout stages.
Former Borussia Dortmund forward and Paraguay international Lucas Barrios recorded a three-goal haul in Gremio's 4-1 rout of 10-man Guarani.
A late penalty helped Botafogo claim a point against Barcelona in the Copa Libertadores.
Fabiano settled the Group 5 contest in the 100th minute as 10-man Palmeiras stayed unbeaten in the Copa Libertadores.