A first-half brace from Andre led the way for Gremio, who set up an all-Brazilian quarter-final against Palmeiras on Thursday.
Boca Juniors were too good for Athletico Paranaense in the last 16 of the Copa Libertadores.
Franco Armani was the hero as River Plate edged Cruzeiro in the last 16 of the Copa Libertadores.
Goals from Diego Tardelli and David Braz helped Gremio beat Libertad in the Copa Libertadores.
Boca Juniors earned a dramatic win at Athletico Paranaense in the first leg of their Copa Libertadores last-16 tie.
Palmeiras salvaged a 2-2 draw at Godoy Cruz in an entertaining first leg of their Copa Libertadores last-16 tie.
Kawhi Leonard looks set to be going head-to-head with LeBron James in Los Angeles, in the latest example of a cross-city rivalry.
The draw for the Copa Libertadores round of 16 took place in Paraguay on Monday.
The pots are set for the last 16, with the draw scheduled to take place in Paraguay on Monday.