Fabio Cannavaro's Guangzhou Evergrande were beaten 2-0 by Urawa Red Diamonds to leave their AFC Champions League final hopes looking thin.
Al-Hilal sealed a comprehensive 4-1 win against Al Sadd on Tuesday to virtually guarantee their place in the AFC Champions League final.
AFC Champions League holders Kashima Antlers' defence of the title was ended by Guangzhou Evergrande in the last eight.
Baghdad Bounedjah scored an 83rd-minute penalty as Al Sadd beat Al-Nassr 3-1 in Monday's second leg to advance 4-3 on aggregate.
Ryohei Shirasaki struck the crossbar late on as Kashima Antlers claimed a 0-0 draw at Guangzhou Evergrande in their quarter-final first leg.
Al-Ittihad and Al-Hilal's AFC Champions League quarter-final is perfectly poised after a goalless first-leg draw.
Shanghai SIPG were indebted to their Brazilian striker Hulk for his spot-kick double against Urawa Red Diamonds at the Shanghai Stadium.
Xavi's Al Sadd took the lead in Monday's AFC Champions League quarter-final first leg, but Al-Nassr came from behind to win 2-1.
Al Sadd saw off Al Duhail in the AFC Champions League last 16, while Al-Hilal survived against Al-Ahli.
Al-Nassr and Al-Ittihad reached the quarter-finals of the AFC Champions League after respective high-scoring wins in the last 16.