Bordeaux Begles gave another demonstration of their Top 14 title credentials with a bonus-point win over Clermont Auvergne.
Top 14 front-runners Lyon won again, while La Rochelle's Arthur Retiere grabbed a hat-trick and Brive left it late.
Northampton Saints and Glasgow Warriors did all they could to stay in the European Champions Cup, while Ulster are definitely through.
Rhys Carre's early red card made life difficult for Saracens, but they still defeated Ospreys in the European Champions Cup.
High-flying pair Lyon and Bordeaux Begles celebrated contrasting victories in Top 14 action on Saturday.
Bordeaux-Begles are back at the top of the Top 14 and increased their advantage over Toulon and Toulouse.
Fly-half Greig Laidlaw said it was an "incredibly hard" decision to retire from international rugby.
Brothers Joe and Sam Simmonds were influential as Exeter Chiefs moved to the brink of a quarter-final spot in Europe.
Bath were no match for a classy Clermonth Auvergne in Friday's European Rugby Champions Cup clash.
Lyon's lead at the Top 14 summit was reduced to just one point as they were comprehensively beaten 33-8 by Montpellier on Saturday.