Top 14 front-runners Lyon won again, while La Rochelle's Arthur Retiere grabbed a hat-trick and Brive left it late.
Stade Francais came into the Clasico sitting bottom of the Top 14, yet they pulled off a thrilling win in Paris as Toulouse wilted.
He may have been granted an early release by Toulon, but Rhys Webb will not play for them again if owner Bernard Lemaitre has his way.
Having been granted an early release from his Toulon contract, Rhys Webb has agreed a return to Ospreys in 2020.
A move to the Ospreys or the Dragons is reportedly on the cards for Rhys Webb after Toulon agreed to release him from his contract early.
Bordeaux-Begles are back at the top of the Top 14 and increased their advantage over Toulon and Toulouse.
Lyon's lead at the Top 14 summit was reduced to just one point as they were comprehensively beaten 33-8 by Montpellier on Saturday.
Toulouse's contrasting home and away form continued as they defeated visitors and 2018-19 Top 14 final opponents Clermont Auvergne.
An early red card was decisive as Bordeaux-Begles suffered their second defeat of the Top 14 season.
Kylan Hamdaoui scored late as Top 14 strugglers Stade Francais edged out Toulon, while Bordeaux-Begles ran riot against Clermont Auvergne.