Ecuador were no match for Argentina on Sunday, as Lionel Scaloni's La Albiceleste claimed a comfortable 6-1 friendly win in Elche.
Chile have confirmed Inter forward Alexis Sanchez, on loan from Manchester United, damaged his left ankle in a game against Colombia.
Paris Saint-Germain star Neymar was substituted in the 12th minute of Brazil's clash with Nigeria due to a suspected hamstring issue.
Lionel Messi is serving a suspension handed down following the Copa America.
A member of Carlos Queiroz's staff was shown a red card during a heated 0-0 draw between Colombia and Chile in Alicante.
Brian Rodriguez's winner helped Uruguay exact some revenge on Peru, who had knocked them out of the Copa America earlier this year.
Brazil are without a win in three matches after drawing 1-1 with Senegal and head coach Tite accepted the criticism aimed his way.
Brazil are winless in three matches after a draw against Senegal and Thiago Silva wants more clinical finishing to get them out of a rut.
Neymar was unable to mark his 100th Brazil appearance with a goal against Senegal, who earned a creditable draw.
Argentina battled back to get a 2-2 draw against Germany on Wednesday, impressing head coach Lionel Scaloni with their collective attitude.