Barcelona forward Luis Suarez is set to make his first Uruguay appearance since the Copa America.
Lionel Messi has not featured for Argentina since the Copa America due to suspension but is back in their squad for November's friendlies.
A sell-out crowd is expected at Wembley for England's friendly against Germany, potentially setting an attendance record for the Lionesses.
Martin Caceres was sent off in the first half but Darwin Nunez struck late as Uruguay drew with Peru in Lima.
Chile edged out Guinea in an international friendly on Tuesday, but Barcelona's Arturo Vidal saw room for improvement in the performance.
Inter have confirmed Alexis Sanchez has damaged a tendon in his left ankle while on duty with Chile and may now require surgery.
A superb first-half display from Northern Ireland was enough to secure a 3-2 win over the Czech Republic at the Generali Arena.
Chile coach Reinaldo Rueda believes Alexis Sanchez could be out for a prolonged period after suffering an ankle injury against Colombia.
Marcos Acuna impressed in Argentina's thrashing of Ecuador and Lucas Alario applauded his performance.
Neymar was withdrawn with a knock during Brazil's friendly against Nigeria, but Tite insists he was not a pre-match worry.