Injury-hit Tottenham lacked a cutting edge in the first leg and RB Leipzig took advantage as they seized a Champions League 1-0 cushion.
St Helens are top of the Super League table with three games played after they beat Hull FC 32-18, while Wakefield Trinity beat Warrington.
Huddersfield Giants and Leeds Rhinos recorded vastly contrasting victories in Friday's two Super League fixtures.
Having fallen behind early on against Bournemouth, Chris Wilder's Sheffield United fought back to claim victory and move up to fifth.
Brisbane Roar continued their strong form with a comeback win over Adelaide United in the A-League.
Real Sociedad knocked Real Madrid out of the Copa del Rey as Alexander Isak netted a quickfire brace after Martin Odegaard was on target.
Melbourne Stars put on an awful chase but will have another crack to reach the BBL final, with Sydney Sixers heading to the showpiece game.
It was a knock for the ages from Marcus Stoinis, who helped the Melbourne Stars to a comfortable Big Bash League win over the Sydney Sixers.
The Melbourne Stars were winners once again in the Big Bash League as Glenn Maxwell punished the sorry Melbourne Renegades.
Real Madrid made light work of Valencia in Jeddah, with Isco particularly impressive in their victory.