Manchester United handed Chelsea a hiding in Frank Lampard's first match in charge. But can he be more Ruud Gullit than Luiz Felipe Scolari?
Maurizio Sarri leaves Chelsea with a strong record, but who have been their most successful recent bosses according to Opta numbers?
Palmeiras reached the knockout phase thanks to a 4-0 rout of Melgar, while San Lorenzo also progressed despite their 1-0 loss to Junior.
Boca assistant Gustavo Barros Schelotto is expecting a tough battle in the Superclasico after his side booked a derby clash with River.
Goals from Dudu and Miguel Borja guided Palmeiras to another win over Colo-Colo.
Luiz Felipe Scolari's Palmeiras left with two priceless away goals in the quarter-final first leg thanks to Bruno Henrique and Dudu.
Miguel Borja scored a second-half brace away from home in Asuncion to put Palmeiras in a strong position on Thursday.
Gamba Osaka, Guangzhou Evergrande Taobao and Jiangsu Suning were the winners in Wednesday's AFC Champions League action.