The Manchester City striker is back in the international fold for Argentina and Sergio Aguero is plotting a return to his homeland.
Monterrey continued Frank de Boer's difficult start to life as Atlanta United head coach.
Tigres UANL reached the CONCACAF Champions League quarter-finals thanks to hat-trick hero Enner Valencia.
Toronto FC will have to overturn a four-goal deficit if they are to progress to the quarter-finals of the CONCACAF Champions League.
River Plate and Gremio will meet in the final four after respective wins against Independiente and Atletico Tucuman.
Mauro Zarate and Pablo Perez helped Boca Juniors to a win over Cruzeiro in the Copa Libertadores.
Independiente were awarded a 3-0 victory just hours before Tuesday's return fixture after Santos fielded an ineligible player.
Santos goalkeeper Vanderlei frustrated a dominant Independiente as the 10-man visitors from Brazil avoided conceding in Argentina.
Juan Ferney Otero scored two second-half penalties to lead Estudiantes past Nacional in the Copa Libertadores.
Corinthians booked their spot in the Copa Libertadores knockout stage as Jadson starred against Deportivo Lara.