Wednesday's results left all three teams on 10 points but Flamengo (+6) and LDU Quito (+4) pipped Penarol (+2) on goal difference.
River Plate progressed to the Copa Libertadores knockout stage after a win at Palestino.
Nicolas De La Cruz's spectacular free-kick helped River Plate earn a draw at Internacional in the Copa Libertadores.
Lucas Viatri led Penarol to a comprehensive win over San Jose in the Copa Libertadores.
Cruzeiro edged Huracan in wet conditions, while Deportivo Lara's clash against Emelec had to be rescheduled due to a floodlight issue.
We assess the leading candidates for glory and the potential stars ahead of the start of the 2019 Copa Libertadores.
Uruguay's fiercest rivalry turned violent on Sunday, forcing the postponement of Nacional v Penarol.